NEFL anticorps

N° du produit ABIN498684

Détail du produit anti-NEFL anticorps

Antigène: NEFL (Neurofilament, Light Polypeptide (NEFL))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEFL est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of NF-L protein. (region surrounding Ile344)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % Sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur NEFL

Antigène: NEFL (Neurofilament, Light Polypeptide (NEFL))

Autre désignation: Neurofilament L (68kDa) (NEFL Produits)

Synonymes: anticorps NEFL, anticorps nefl, anticorps zgc:136626, anticorps AI847934, anticorps CMT2E, anticorps NF-L, anticorps NF68, anticorps Nfl, anticorps CMT1F, anticorps NFL, anticorps XNF-L, anticorps neurofilament light, anticorps neurofilament, light polypeptide, anticorps neurofilament, light polypeptide b, anticorps neurofilament, light L homeolog, anticorps NEFL, anticorps neflb, anticorps Nefl, anticorps nefl.L

Sujet: Neurofilament-L (for neurofilament light polypeptide, or NF-L), a member of the intermediate filament family, is a major component of neuronal cytoskeletons. Neurofilaments are dynamic structures, they contain phosphorylation sites for a large number of protein kinases, including protein kinase A, protein kinase C, cyclin-dependent kinase 5, extracellular signal regulated kinase, glycogen synthase kinase-3, and stress-activated protein kinase gamma. In addition to their role in the control of axon caliber, neurofilaments may affect other cytoskeletal elements, such as microtubules and actin filaments. Changes in neurofilament phosphorylation or metabolism are frequently observed in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS),Parkinson's disease, and Alzheimer's disease.Synonyms: 68 kDa neurofilament protein, NEFL, NF-L, NF68, Neurofilament L

Poids moléculaire: approx. 62 kDa

ID gène: 4747

NCBI Accession: NP_006149

UniProt: P07196