HSF1 anticorps (pSer303)
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- Antigène Voir toutes HSF1 Anticorps
- HSF1 (Heat Shock Factor Protein 1 (HSF1))
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Épitope
- pSer303
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HSF1 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- This antibody detects endogenous levels of p-HSF1 protein.
- Réactivité croisée (Details)
- Species reactivity (tested):Human and Mouse.
- Purification
- Affinity chromatography
- Pureté
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product HSF1 Anticorps primaire
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- Indications d'application
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- HSF1 (Heat Shock Factor Protein 1 (HSF1))
- Autre désignation
- Heat Shock Factor 1 / HSF1 (HSF1 Produits)
- Synonymes
- anticorps hsf1, anticorps Hsf, anticorps xhsf1, anticorps AA960185, anticorps HSTF1, anticorps HSF1, anticorps HSF, anticorps HSF1c, anticorps hsf1a, anticorps hsf1b, anticorps zHSF1a, anticorps zHSF1b, anticorps hstf1, anticorps heat shock factor, anticorps Heat Shock Factor, anticorps heat shock factor 1, anticorps heat shock transcription factor 1, anticorps heat shock transcription factor 1 S homeolog, anticorps hsf1, anticorps hsf-1, anticorps Hsf1, anticorps HSF1, anticorps hsf1.S
- Sujet
- Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors (HSF, also designated HSTF) 1 and 2 are involved in this regulation. HSF1 and HSF2 are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSF2 activity is associated with differentiation and development and, like HSF1, binds DNA as a trimer. Both HSF1 and HSF2 are known to be induced by proteasome inhibitors of the ubiquitin pathway. Phosphorylation of HSF1 on Ser 230 by heat shock has been shown to positively contribute to the transcriptional activity of HSF1.Synonyms: HSF-1, HSTF1, Heat shock transcription factor 1
- Poids moléculaire
- approx. 82 kDa
- ID gène
- 3297
- NCBI Accession
- NP_005517
- UniProt
- Q00613
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