KDELR2 anticorps

N° du produit ABIN498960

Détail du produit anti-KDELR2 anticorps

Antigène: KDELR2 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 2 (KDELR2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDELR2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of KDEL Receptor 2 protein. (region surrounding Leu119)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur KDELR2

Antigène: KDELR2 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 2 (KDELR2))

Autre désignation: KDEL Receptor 2 / KDELR2 (KDELR2 Produits)

Synonymes: anticorps kdelr2, anticorps ELP-1, anticorps ERD2.2, anticorps 1110007A14Rik, anticorps kdelr1-a, anticorps KDEL endoplasmic reticulum protein retention receptor 2 L homeolog, anticorps KDEL endoplasmic reticulum protein retention receptor 2, anticorps KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, anticorps KDEL endoplasmic reticulum protein retention receptor 1 L homeolog, anticorps kdelr2.L, anticorps KDELR2, anticorps Kdelr2, anticorps kdelr1.L

Sujet: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-gluleu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.Synonyms: ELP-1, ER lumen protein retaining receptor 2, ERD2-like protein 1, ERD2.2, KDEL endoplasmic reticulum protein retention receptor 2

Poids moléculaire: approx. 24 kDa

ID gène: 11014

NCBI Accession: NP_006845

UniProt: P33947

Pathways: Maintenance of Protein Location