BAK1 anticorps (N-Term)

N° du produit ABIN499405

Cet anticorps Lapin Polyclonal détecte spécifiquement BAK1 dans WB, IF et EIA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour BAK1 anticorps (N-Term) (ABIN499405)

Antigène: BAK1 (BCL2-Antagonist/killer 1 (BAK1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAK1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-BAK1 anticorps

Épitope: N-Term

Specificité: Bak antibody was raised against a peptide corresponding to 13 amino acids near the amino-terminus of human Bak.

Purification: Ion exchange chromatography

Immunogène: Human Bak (N-Terminus) Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Bak antibody can be used for detection of Bak at 1 to 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur BAK1

Antigène: BAK1 (BCL2-Antagonist/killer 1 (BAK1))

Autre désignation: Bcl-2-Like 7

Sujet: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bak, a pro-apoptotic Bcl-2 family member, is an oligomeric protein that localizes to the mitochondria (4,5). It is thought to share significant functional homology with Bax, another pro-apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability (6,7).Synonyms: Apoptosis regulator BAK, BAK, BAK1, BCL2L7, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 7, Bcl2-L-7, CDN1, cell death inhibitor 1

ID gène: 578

UniProt: Q16611

Pathways: Apoptose, Steroid Hormone Mediated Signaling Pathway, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response