CDK5 anticorps (AA 15-100) (AbBy Fluor® 750)
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- Antigène Voir toutes CDK5 Anticorps
- CDK5 (Cyclin-Dependent Kinase 5 (CDK5))
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Épitope
- AA 15-100
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CDK5 est conjugé à/à la AbBy Fluor® 750
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Specificité
- This antibody will detect both isoform variants of this protein. Due to similar amino acid composition of this protein to CDK3 in human, there is a chance that this antibody will react with CDK3 in human, based on an 83 % sequence similarity.
- Réactivité croisée
- Humain, Souris, Rat
- Homologie
- Cow,Pig
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human CDK5
- Isotype
- IgG
- Top Product
- Discover our top product CDK5 Anticorps primaire
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- Indications d'application
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- CDK5 (Cyclin-Dependent Kinase 5 (CDK5))
- Autre désignation
- CDK5 (CDK5 Produits)
- Synonymes
- anticorps PSSALRE, anticorps AW048668, anticorps Crk6, anticorps CDK5, anticorps CG8203, anticorps DmCdk5, anticorps Dmel\\CG8203, anticorps cdk5, anticorps zgc:101604, anticorps cyclin dependent kinase 5, anticorps cyclin-dependent kinase 5, anticorps Cyclin-dependent kinase 5, anticorps cyclin-dependent kinase 5 L homeolog, anticorps Cyclin-dependent-like kinase 5, anticorps CDK5, anticorps Cdk5, anticorps cdk5, anticorps cdk5.L, anticorps cdk-5
- Sujet
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Synonyms: PSSALRE, Cyclin-dependent-like kinase 5, Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit, CDK5, CDKN5
Background: CDK5 is serine/threonine kinase involved in synaptic regulation and neuronal development, phosphorylates synaptic protein Pctaire1, regulates acetylcholine receptor expression.CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.
- ID gène
- 1020
- UniProt
- Q00535
- Pathways
- Cycle Cellulaire, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis
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