FANCA anticorps (AA 461-560) (Alexa Fluor 750)

N° du produit ABIN5002446

Détail du produit anti-FANCA anticorps (Alexa Fluor 750)

Antigène: FANCA (Fanconi Anemia Group A Protein (FANCA))

Épitope: AA 461-560

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FANCA est conjugé à/à la Alexa Fluor 750

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Rat

Homologie: Human,Mouse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FANCA

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur FANCA

Antigène: FANCA (Fanconi Anemia Group A Protein (FANCA))

Autre désignation: FANCA (FANCA Produits)

Synonymes: anticorps FA, anticorps FA-H, anticorps FA1, anticorps FAA, anticorps FACA, anticorps FAH, anticorps FANCH, anticorps AW208693, anticorps Fanconi anemia complementation group A, anticorps Fanconi anemia, complementation group A, anticorps FANCA, anticorps Fanca

Sujet:

Synonyms: FA 1, FA, FA H, FA1, FAA, FACA, FAH, Fanca, FANCA_HUMAN, FANCH, Fanconi anemia complementation group A, Fanconi anemia complementation group H, Fanconi anemia group A protein, Fanconi anemia type 1, MGC75158, Protein FACA.

Background: Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. At least eight complementation groups (A-G) have been identified and six FA genes (for subtypes A, C, D2, E, F and G) have been cloned. The FA proteins lack sequence homologies or motifs that could point to a molecular function. The cellular accumulation of FA proteins, including FANCA and FANCG, is subject to regulation by TNF alpha signaling. Phosphorylation of FANC (Fanconi anemia complementation group) proteins is thought to be important for the function of the FA pathway. FANCA, also known as FACA and FANCH, associates with the Brm-related gene 1 (BRG1) product, a subunit of the SWI/SNF complex which remodels chromatin structure through a DNA-dependent ATPase activity. FANCA is mainly expressed in lymphoid tissues, testis and ovary. The amino-terminal region of the FANCA protein is required for FANCG binding, FANCC binding, nuclear localization and functional activity of the complex. The human FANCA gene maps to chromosome 16q24.3 and encodes a 1,455 amino acid protein.

ID gène: 2175

Pathways: Réparation de l'ADN