SARM1 anticorps (C-Term)

N° du produit ABIN500660

Il existe 2+ publications pour ce produit. L’anticorps anti-SARM1 Polyclonal Lapin est utilisé pour la détection de SARM1 dans des échantillons de Humain et Souris. Il a été validé pour WB, IF et EIA.

Aperçu rapide pour SARM1 anticorps (C-Term) (ABIN500660)

Antigène: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SARM1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-SARM1 anticorps

Épitope: C-Term

Specificité: This antibody detects SARM1 at C-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Ion exchange chromatography

Immunogène: SARM antibody was raised against a peptide corresponding to amino acids near the C- terminus of human SARM.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 to 2 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-SARM1 (ABIN500660)

Chintala, Putris, Geno: "Activation of TLR3 promotes the degeneration of retinal ganglion cells by upregulating the protein levels of JNK3." dans: Investigative ophthalmology & visual science, Vol. 56, Issue 1, pp. 505-14, (2015) (PubMed).

Massoll, Mando, Chintala: "Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons." dans: Investigative ophthalmology & visual science, Vol. 54, Issue 4, pp. 2771-80, (2013) (PubMed).

Détails sur SARM1

Antigène: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Autre désignation: SARM1

Sujet: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-kappaB, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interluekin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.Synonyms: KIAA0524, SAM domain-containing protein 2, SAMD2, SARM, Sterile alpha and Armadillo repeat protein, Sterile alpha and TIR motif-containing protein 1, Sterile alpha motif domain-containing protein 2

ID gène: 23098

NCBI Accession: NP_055892

UniProt: Q6SZW1

Pathways: Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades