SOX2 anticorps
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- Antigène Voir toutes SOX2 Anticorps
- SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SOX2 est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- Protein A Chromatography
- Immunogène
- A full length recombinant Sox2 protein was used as the immunogen for this antibody.
- Isotype
- IgG
- Top Product
- Discover our top product SOX2 Anticorps primaire
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- Indications d'application
- WB: 1-2 μg/mL
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- PBS containing 0.05 % BSA, PH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- Antigène
- SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))
- Autre désignation
- SOX2 (SOX2 Produits)
- Synonymes
- anticorps ANOP3, anticorps MCOPS3, anticorps RGD1565646, anticorps Sox-2, anticorps lcc, anticorps ysb, anticorps cb236, anticorps wu:fb83g04, anticorps wu:fc14d07, anticorps zgc:65860, anticorps zgc:77389, anticorps SRY-box2, anticorps Xsox-2, anticorps anop3, anticorps mcops3, anticorps sox-2, anticorps SRY-box 2, anticorps SRY box 2, anticorps SRY (sex determining region Y)-box 2, anticorps SRY-box 2 S homeolog, anticorps SOX2, anticorps Sox2, anticorps sox2, anticorps sox2.S
- Sujet
- SOX2 is a member of the SRY-related HMG-box (SOX) transcription factor family with a set of well-established and diverse roles in stem cell potency and maintenance, embryonic development and cancer. It regulates extensive and often divergent transcriptional networks across different cell types. SOX2 is best known as a core pluripotency factor, maintaining the undifferentiated phenotype of pluripotent stem cells, and is closely co-regulated alongside core pluripotency factors OCT4 and NANOG in undifferentiated ESCs (Embryonic Stem Cells), ECCs (Embryonal Carcinoma Cells) and iPSCs (Induced Pluripotent Stem Cells). Loss of SOX2 expression in these cell lines triggers their differentiation. More recently, SOX2 has been identified as a crucial player in the maintenance and differentiation of adult stem cells such as in neural stem cells. Moreover, high expression levels of SOX2 correlate with tumor progression or poor prognosis of multiple cancers. In contrast, the tumor-suppressive role of SOX2 has been reported in gastric cancer and squamous cell lung cancer.
- Poids moléculaire
- 34 kDa
- ID gène
- 6657
- UniProt
- P48431
- Pathways
- Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis
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