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SMARCB1 anticorps (AA 11-231)
SMARCB1
Reactivité: Humain
WB
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN5027323
Détail du produit anti-SMARCB1 anticorps
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Antigène
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SMARCB1
(SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1))
Épitope
Tous les épitopes à travers SMARCB1 Anticorps.
AA 11-231
Reactivité
Toutes les réactivités sur SMARCB1 Anticorps
Humain
Hôte
Toutes les hôtes sur SMARCB1 Anticorps
Lapin
Clonalité
Toutes les clonalités sur SMARCB1 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers SMARCB1 Anticorps
Cet anticorp SMARCB1 est non-conjugé
Application
Tous les applications à travers SMARCB1 Anticorps.
Western Blotting (WB)
Purification
Protein A Chromatography
Immunogène
A partial length recombinant INI-1/SNF5 protein (amino acids 11-231) was used as the immunogen for this antibody.
Isotype
IgG
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Alternatives
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anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) (AA 301-385) antibody
SMARCB1
Reactivité: Humain, Souris
ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Hôte: Lapin
Polyclonal
unconjugated
Information d'application
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Indications d'application
WB: 1-2 μg/mL
Restrictions
For Research Use only
Stockage
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Concentration
0.5 mg/mL
Buffer
PBS containing 0.05 % BSA, PH 7.4
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Détails sur SMARCB1
(cache)
Antigène
SMARCB1
(SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1))
Autre désignation
INI-1/SNF5 (SMARCB1 Produits )
Synonymes
anticorps SMARCB1, anticorps BAF47, anticorps INI1, anticorps MRD15, anticorps RDT, anticorps RTPS1, anticorps SNF5, anticorps SNF5L1, anticorps Sfh1p, anticorps Snr1, anticorps hSNFS, anticorps AU020204, anticorps Baf47, anticorps Ini1, anticorps SNF5/INI1, anticorps Snf5, anticorps fc51b01, anticorps smarcb1, anticorps wu:fc51b01, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 S homeolog, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b, anticorps SMARCB1, anticorps Smarcb1, anticorps smarcb1.S, anticorps smarcb1b
Sujet
SNF5/INI1 is the core subunit of the SWI/SNF chromatin remodeling complex that contributes to the regulation of chromatin structure. It is a tumor suppressor in humans and mice, with an essential role in early embryonic development. SNF5 interacts with UV damage recognition factor XPC and colocalizes at the damage site upon UV irradiation. Inactivation of SNF5 affects the recruitment of ATM checkpoint kinase to the damage site and ATM activation by phosphorylation. SNF5 deficiency results in a defect in H2AX and BRCA1 phosphorylation at the damage site. SNF5/INI1 forms a functional complex with p300/GATA4 on hypertrophic response gene promoters in cardiomyocytes. It plays an inhibitory role in cardiomyocyte hypertrophy by suppressing p300/GATA4-dependent transcription. SNF5 genetic mutations were first reported in malignant rhabdoid tumors.
Poids moléculaire
40 kDa
ID gène
6598
UniProt
Q12824
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