PTH anticorps (AA 1-236)
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- Antigène Voir toutes PTH Anticorps
- PTH (Parathyroid Hormone (PTH))
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Épitope
- AA 1-236
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PTH est non-conjugé
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Application
- Immunohistochemistry (IHC), Western Blotting (WB)
- Purification
- Protein G Chromatography
- Immunogène
- A partial length recombinant Parathyroid Hormone protein (amino acids 1-236) was used as the immunogen for this antibody
- Clone
- ABM4D44
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product PTH Anticorps primaire
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- Indications d'application
- WB: 2-4 μg/mL, IHC: 5 μg/mL
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- PBS containing 0.05 % BSA, PH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- Antigène
- PTH (Parathyroid Hormone (PTH))
- Autre désignation
- Parathyroid Hormone (PTH Produits)
- Synonymes
- anticorps PTH1, anticorps Pthp, anticorps PTH-(1-84), anticorps Pth1, anticorps Pthr1, anticorps PTH, anticorps parathyroid hormone, anticorps parathyroid hormone S homeolog, anticorps PTH, anticorps Pth, anticorps pth.S
- Classe de substances
- Hormone
- Sujet
- Parathyroid hormone (PTH) produced and secreted by parathyroid glands, maintains mineral homeostasis by regulating calcium and phosphate absorption/reabsorption. It modulates phosphate homeostasis by downregulating Dentin matrix acidic phosphoprotein 1(DMP1) expression via the cAMP/PKA pathway targeting genes/proteins mutually governed by PTH. PTH secretion is characterized by an ultradian rhythm with tonic and pulsatile components. The majority of PTH is secreted in tonic fashion. Changes in the ultradian PTH secretion are correlated with skeletal fragility in primary and secondary osteoporosis. Plasma concentrations of Zn ions levels were significantly correlated with PTH levels. PTH in serum is typical for patients with chronic kidney disease (CKD). The onset of CKD is associated with pathway changes of protein synthesis and metabolism, amino acid metabolism, energy metabolism, and steroid hormone metabolism. Parathyroid hormones are bone-forming agents that have different modes of action on the bone. Lack of PTH in the central nervous system causes Hypoparathyroidism (HPT).
- Poids moléculaire
- 59 kDa
- ID gène
- 5745
- UniProt
- Q03431
- Pathways
- cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process
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