SOX10 anticorps (AA 115-269)

N° du produit ABIN5027533

Détail du produit anti-SOX10 anticorps

Antigène: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Épitope: AA 115-269

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SOX10 est non-conjugé

Application: Western Blotting (WB)

Purification: Protein G Chromatography

Immunogène: A partial length recombinant SOX-10 protein (amino acids 115-269) was used as the immunogen for this antibody.

Clone: ABM4E24

Isotype: IgG2b kappa

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur SOX10

Antigène: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Autre désignation: SOX10 (SOX10 Produits)

Synonymes: anticorps DOM, anticorps PCWH, anticorps WS2E, anticorps WS4, anticorps WS4C, anticorps SOX-10, anticorps SOX10, anticorps dom, anticorps ws4, anticorps Dom, anticorps Sox21, anticorps SOX9, anticorps cls/sox10, anticorps zgc:100757, anticorps SRY-box 10, anticorps SRY box 10, anticorps SRY-box 10 L homeolog, anticorps SRY (sex determining region Y)-box 10, anticorps SOX10, anticorps Sox10, anticorps sox10.L, anticorps sox10

Sujet: SOX10 is a transcription factor that belongs to the high mobility group (HMG) box super family of DNA-binding proteins. It is located at 22q13.1 and is highly conserved in vertebrates. SOX10 is expressed in many different cell types and tissues and implicated in neural crest development, nervous system neurogenesis, as well as differentiation of oligodendrocyte, glia and melanocytes. It modulates other transcription factors including PAX3 forming a complex and acts as a nucleocytoplasmic shuttle protein in neural crest and oligodendrocyte development. The level of expression of SOX10 plays pivotal regulatory role both in tumor progression and suppression. Its elevated expression, possess tumor-promoting activities in several malignancies including melanoma and gliomas. Decreased expression of SOX10 promotes tumor cell growth and focal adhesions of Merlin-null schwannoma cells. SOX10 may also function as a tumor suppressor by inducing tumor cell apoptosis, inhibiting invasion, regulating cell EMT and stemness through suppressing Wnt/Beta-catenin signaling. Mutations of the Sox10 gene are known to cause various combinations of hearing loss and pigmentation defects in humans such as Waardenburg syndrome, a rare auditory-pigmentary disorder that generates varying combinations of hearing loss and pigmentation defects.

Poids moléculaire: 50 kDa

ID gène: 6663

UniProt: P56693

Pathways: Chromatin Binding