DFFA anticorps (Middle Region)

N° du produit ABIN5514702

Détail du produit anti-DFFA anticorps

Antigène: DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DFFA est non-conjugé

Application: Western Blotting (WB)

Séquence: DYFLCLPSNT KFVALASNEK WAYNNSDGGT AWISQESFDV DETDSGAGLK

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human DFFA

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur DFFA

Antigène: DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

Autre désignation: DFFA (DFFA Produits)

Synonymes: anticorps DFF-45, anticorps DFF1, anticorps ICAD, anticorps A330085O09Rik, anticorps DFF35, anticorps Dff45, anticorps ICAD-L, anticorps ICAD-S, anticorps DFFA, anticorps zgc:92229, anticorps DNA fragmentation factor subunit alpha, anticorps DNA fragmentation factor, alpha subunit, anticorps DNA fragmentation factor, 45kDa, alpha polypeptide, anticorps DNA fragmentation factor, alpha polypeptide, anticorps DFFA, anticorps Dffa, anticorps dffa

Sujet: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alias Symbols: DFF1, ICAD, DFF-45,

Protein Size: 167

ID gène: 1676

NCBI Accession: NM_004401, NP_004392

UniProt: O00273

Pathways: Apoptose, Caspase Cascade in Apoptosis