UNC13B anticorps (Middle Region)

N° du produit ABIN5515349

Détail du produit anti-UNC13B anticorps

Antigène: UNC13B (Unc-13 Homolog B (UNC13B))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UNC13B est non-conjugé

Application: Western Blotting (WB)

Séquence: SYDLDYPERR AISPTSSSRY GSSCNVSQGS SQLSELDQYH EQDDDHRETD

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human UNC13B

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur UNC13B

Antigène: UNC13B (Unc-13 Homolog B (UNC13B))

Autre désignation: UNC13B (UNC13B Produits)

Synonymes: anticorps MUNC13, anticorps UNC13, anticorps Unc13h2, anticorps UNC13B, anticorps Munc13-2, anticorps Munc13-1, anticorps Unc13a, anticorps Unc13h1, anticorps unc-13 homolog B, anticorps unc-13 homolog B (C. elegans), anticorps UNC13B, anticorps Unc13b

Sujet: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

Alias Symbols: UNC13, MUNC13, Unc13h2

Protein Size: 1591

ID gène: 10497

NCBI Accession: NM_006377, NP_006368

UniProt: O14795

Pathways: Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis