PRKG1 anticorps (C-Term)

N° du produit ABIN5515898

Détail du produit anti-PRKG1 anticorps

Antigène: PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKG1 est non-conjugé

Application: Western Blotting (WB)

Séquence: FNWEGLRKGT LTPPIIPSVA SPTDTSNFDS FPEDNDEPPP DDNSGWDIDF

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human PRKG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PRKG1

Antigène: PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))

Autre désignation: PRKG1 (PRKG1 Produits)

Synonymes: anticorps prkg1, anticorps zgc:63955, anticorps Pkgi, anticorps cGk1, anticorps 1, anticorps PKG, anticorps PRKG1B, anticorps PRKGR1B, anticorps cGK, anticorps cGK 1, anticorps cGK1, anticorps cGKI, anticorps cGKI-BETA, anticorps cGKI-alpha, anticorps CGKI, anticorps cGKI-beta, anticorps AW125416, anticorps Gm19690, anticorps Prkg1b, anticorps Prkgr1b, anticorps Prkg1beta, anticorps protein kinase, cGMP-dependent, type Ia, anticorps protein kinase, cGMP-dependent, type I, anticorps protein kinase, cGMP-dependent, type 1, anticorps prkg1a, anticorps PRKG1, anticorps prkg1, anticorps Prkg1

Sujet: Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.

Alias Symbols: PKG, cGK, AAT8, cGK1, cGKI, cGK 1, PRKG1B, PRKGR1B, cGKI-BETA, cGKI-alpha

Protein Size: 389

ID gène: 5592

NCBI Accession: NM_001098512, NP_001091982