ATG14 anticorps (Middle Region)

N° du produit ABIN5516479

Détail du produit anti-ATG14 anticorps

Antigène: ATG14 (ATG14 Autophagy Related 14 (ATG14))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG14 est non-conjugé

Application: Western Blotting (WB)

Séquence: NEEMEKNSEG LLKTKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ATG14

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ATG14

Antigène: ATG14 (ATG14 Autophagy Related 14 (ATG14))

Autre désignation: ATG14 (ATG14 Produits)

Synonymes: anticorps ATG14L, anticorps BARKOR, anticorps KIAA0831, anticorps 4832427M01, anticorps Atg14L, anticorps D14Ertd114e, anticorps D14Ertd436e, anticorps RGD1304610, anticorps autophagy related 14, anticorps ATG14, anticorps Atg14

Sujet: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion. Modulates the hepatic lipid metabolism.

Alias Symbols: ATG14L, BARKOR, KIAA0831

Protein Size: 492

ID gène: 22863

NCBI Accession: NM_014924, NP_055739

UniProt: Q6ZNE5

Pathways: Autophagy