KIDINS220 anticorps (Middle Region)

N° du produit ABIN5516661

Détail du produit anti-KIDINS220 anticorps

Antigène: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIDINS220 est non-conjugé

Application: Western Blotting (WB)

Séquence: VERVPKSPEH SAEPIRTFIK AKEYLSDALL DKKDSSDSGV RSSESSPNHS

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rat: 100%, Zebrafish: 93%

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human KIDINS220

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur KIDINS220

Antigène: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Autre désignation: KIDINS220 (KIDINS220 Produits)

Synonymes: anticorps ARMS, anticorps fj35h03, anticorps kidins220, anticorps zgc:63531, anticorps dZ119J18.2, anticorps wu:fj35h03, anticorps 3110039L19Rik, anticorps AI194387, anticorps AI316525, anticorps C330002I19Rik, anticorps mKIAA1250, anticorps kinase D interacting substrate 220, anticorps kinase D-interacting substrate 220, anticorps kinase D-interacting substrate 220b, anticorps kinase D-interacting substrate 220kDa, anticorps KIDINS220, anticorps Kidins220, anticorps kidins220b

Sujet: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Alias Symbols: ARMS

Protein Interaction Partner: UBC, LGR4, MYC, FN1, MOB4, CDC73, PRKD1, CRKL, NTRK2, NTRK3, NTRK1, NGFR,

Protein Size: 59

Poids moléculaire: 543 kDa

ID gène: 57498