KDM5B anticorps (C-Term)

N° du produit ABIN5517137

Détail du produit anti-KDM5B anticorps

Antigène: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM5B est non-conjugé

Application: Western Blotting (WB)

Séquence: EMKKFPDNDL LRHLRLVTQD AEKCASVAQQ LLNGKRQTRY RSGGGKSQNQ

Attributs du produit: This is a rabbit polyclonal antibody against KDM5B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human KDM5B

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur KDM5B

Antigène: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Autre désignation: KDM5B (KDM5B Produits)

Synonymes: anticorps jarid1b, anticorps jarid1ba, anticorps id:ibd5050, anticorps wu:fd15c05, anticorps cb264, anticorps jarid1bb, anticorps plu1, anticorps wu:fc44h11, anticorps zgc:85741, anticorps JARID1B, anticorps CT31, anticorps PLU-1, anticorps PLU1, anticorps PUT1, anticorps RBBP2H1A, anticorps 2010009J12Rik, anticorps 2210016I17Rik, anticorps AW556288, anticorps D1Ertd202e, anticorps Jarid1b, anticorps Plu1, anticorps Rb-Bp2, anticorps mKIAA4034, anticorps RGD1565602, anticorps lysine (K)-specific demethylase 5Ba, anticorps lysine (K)-specific demethylase 5Bb, anticorps lysine demethylase 5B, anticorps lysine (K)-specific demethylase 5B, anticorps kdm5ba, anticorps kdm5bb, anticorps KDM5B, anticorps Kdm5b

Sujet: KDM5B is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.

Alias Symbols: KDM5B, JARID1B, PLU1, RBBP2H1,

Protein Interaction Partner: FBXW11, UBC, HDAC2, HDAC4, SUMO1, SUMO3, PPP1CA, TFAP2C, MYC, HDAC7, HDAC5, NCOR1, PAX9, HDAC1, ELAVL1, CHD3, MTA3, MBD3, KDM1A, MTA2, MBD2, RBBP7, RBBP4, RB1, SUMO2, KLF10, LMO2, FOXG1, AR, VGLL3, PRDM13, ARID1B, BMP2K, RNF43, RBM15B, DBNL, CECR6, SLC39A

Protein Size: 1544

ID gène: 10765

NCBI Accession: NP_006609

UniProt: Q9UGL1

Pathways: L'effet Warburg