TIM3 anticorps (N-Term)
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- Antigène Voir toutes TIM3 (TIM 3) Anticorps
- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
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Épitope
- N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TIM3 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- At least two antibodies are known to exist, this antibody will detect both isoforms.
- Purification
- TIM3 Antibody is affinity chromatography purified via peptide column.
- Immunogène
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TIM3 antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human TIM3.
The immunogen is located within amino acids 60 - 110 of TIM3. - Isotype
- IgG
- Top Product
- Discover our top product TIM 3 Anticorps primaire
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- Indications d'application
- TIM3 antibody can be used for Western blot at 1 - 2 μ,g/mL.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- TIM3 Antibody is supplied in PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- TIM3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Antigène
- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
- Autre désignation
- TIM3 (TIM 3 Produits)
- Synonymes
- anticorps HAVCR2, anticorps MGC140131, anticorps HAVcr-2, anticorps KIM-3, anticorps TIM3, anticorps TIMD-3, anticorps TIMD3, anticorps Tim-3, anticorps TIM-3, anticorps Tim3, anticorps Timd3, anticorps tim3, anticorps hepatitis A virus cellular receptor 2, anticorps HAVCR2, anticorps Havcr2
- Classe de substances
- Virus
- Sujet
- The immune checkpoint protein TIM3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-γ producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1). TIM3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice, blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3).
- Poids moléculaire
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Predicted: 33 kDa
Observed: 37 kDa - ID gène
- 84868
- NCBI Accession
- NP_116171
- UniProt
- Q8TDQ0
- Pathways
- Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
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