STK3 anticorps (C-Term)

N° du produit ABIN5537151

Détail du produit anti-STK3 anticorps

Antigène: STK3 (serine/threonine Kinase 3 (STK3))

Épitope: AA 387-415, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STK3 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Stk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-415 amino acids from the C-terminal region of mouse Stk3.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur STK3

Antigène: STK3 (serine/threonine Kinase 3 (STK3))

Autre désignation: Stk3 (STK3 Produits)

Synonymes: anticorps KRS1, anticorps MST2, anticorps 0610042I06Rik, anticorps MST, anticorps Mst2, anticorps Mst3, anticorps Ste20, anticorps mess1, anticorps mst2, anticorps xstk3, anticorps wu:fc19e11, anticorps zgc:55383, anticorps serine/threonine kinase 3, anticorps serine/threonine kinase 3 S homeolog, anticorps serine/threonine kinase 3 (STE20 homolog, yeast), anticorps STK3, anticorps Stk3, anticorps stk3.S, anticorps stk3

Sujet: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1.

Poids moléculaire: 57 kDa

ID gène: 56274

UniProt: Q9JI10

Pathways: Tube Formation