NME3 anticorps (AA 51-81)

N° du produit ABIN5538404

Détail du produit anti-NME3 anticorps

Antigène: NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3 (NME3))

Épitope: AA 51-81

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NME3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogène: This NME3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-81 amino acids from the Central region of human NME3.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur NME3

Antigène: NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3 (NME3))

Autre désignation: NME3 (NME3 Produits)

Synonymes: anticorps DR-nm23, anticorps NDPK-C, anticorps NDPKC, anticorps NM23-H3, anticorps NM23H3, anticorps c371H6.2, anticorps 1810009F08Rik, anticorps AI413736, anticorps Ndk3, anticorps Nm23-DR, anticorps Nm23-M3, anticorps NME/NM23 nucleoside diphosphate kinase 3, anticorps NME3, anticorps Nme3

Sujet: NME3 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34(+) cells. Its constitutive expression in a myeloid precursor line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death. These results appear consistent with a role for the NME3 gene in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.

Poids moléculaire: 19 kDa

ID gène: 4832

UniProt: Q13232

Pathways: Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process