JAK2 anticorps

N° du produit ABIN5541875

Cet anticorps Lapin Polyclonal détecte spécifiquement JAK2 dans WB et EIA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour JAK2 anticorps (ABIN5541875)

Antigène: JAK2 (Janus Kinase 2 (JAK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JAK2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-JAK2 anticorps

Specificité: This antibody reacts with the 130 kDa JAK2 on human and other species with consensus sequence.

Purification: Protein G affinity

Immunogène: Synthetic peptide derived from the human JAK2 peptide, conjugated with KLH

Information d'application

Indications d'application: ELISA: 1/64,000 for detection of the JAK2 peptide coated on ELISA plate. Western blot: 1/2,000 to detect 130 kDa JAK2 in TF-1 cell extract.

Restrictions: For Research Use only

Stockage

Buffer: 0.01M PBS, pH 7.4

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur JAK2

Antigène: JAK2 (Janus Kinase 2 (JAK2))

Autre désignation: tyrosine-protein kinase jak2

Sujet: Janus kinase 2 (JAK2) is a non-receptor tyrosine kinase that plays an important role in signal transduction through its association with receptors on the cell membrane. When these receptors are activated by extracellular signals, the receptors activate JAK2 which in turn phosphorylates the tyrosine residues on the receptors. The phosphorylation enables the binding of downstream signaling molecules, primarily, signal transducer and activator of transcription (STAT) proteins. STATs possess a SHdomain that specifically binds to phosphorylated tyrosine residue on the receptor. STAT in cytoplasma is activated after binding and migrates to nucleus to activate gene transcription. JAK2 mediates the transduction of a variety of extracellular signals in this pattern. The receptors that are associated with JAK2 include type II cytokine receptors, GM-CSF receptor family, gp130 receptor family, growth hormone receptor, prolactin receptor and EPO receptor.

UniProt: O60674

Pathways: Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response