ADAM17 anticorps (C-Term)

N° du produit ABIN6259765

Cet anticorps anti-ADAM17 Polyclonal Lapin (ABIN6259765) détecte spécifiquement ADAM17 dans WB, ICC et IF. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour ADAM17 anticorps (C-Term) (ABIN6259765)

Antigène: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADAM17 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-ADAM17 anticorps

Épitope: C-Term

Fonction: ADAM 17 Antibody

Specificité: ADAM 17 Antibody detects endogenous levels of total ADAM 17.

Homologie: Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ADAM 17, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ADAM17

Antigène: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Autre désignation: ADAM 17

Sujet:

Description: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

Gene: ADAM17

Poids moléculaire: 93 kDa

ID gène: 6868

UniProt: P78536

Pathways: Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus