HES1 anticorps

N° du produit ABIN5564238

Détail du produit anti-HES1 anticorps

Antigène: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HES1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Specificité: Recognizes human, mouse and rat HES1.

Réactivité croisée: Humain, Souris, Rat (Rattus)

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant human Hes1 protein fused to a His-tag.

Clone: 7H11

Isotype: IgG2b

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: HEPES with 0.15M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur HES1

Antigène: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Autre désignation: Hairy and Enhancer of Split 1 (HES1 Produits)

Synonymes: anticorps HES-1, anticorps HHL, anticorps HRY, anticorps bHLHb39, anticorps Hry, anticorps HAIRY1, anticorps c-hairy1A, anticorps Xhairy1, anticorps hairy1, anticorps hes1, anticorps Xhairy-1, anticorps Xlh1, anticorps hes family bHLH transcription factor 1, anticorps hairy and enhancer of split 1 (Drosophila), anticorps hes family bHLH transcription factor 4, anticorps hes family bHLH transcription factor 1 S homeolog, anticorps hes family bHLH transcription factor 1 L homeolog, anticorps HES1, anticorps Hes1, anticorps HES4, anticorps hes1.S, anticorps hes1.L

Sujet: The Notch signaling pathway is important for cell-cell communication, which involve gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. It critically influences cell proliferation, differentiation, and apoptosis in metazoans. The hairy and enhancer of split (HES) family is a basic helix-loop-helix (bHLH) type trancriptional repressor and acts as Notch effectors by negatively regulating expression of downstream target genes such as tissue-specific transcription factors. HES-1 is an upstream negative regulator of REST expression. Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and beta-cells. Recent integrative genomic analyses on HES/HEY family suggest that HES1 and HES3 are target genes of the embryonic stem cell-specific network of transcription factors, and that HES1, HES5, HEY1, HEY2 and HEYL are target genes of Notch signaling pathway.

Pathways: Réparation de l'ADN