TLR7 anticorps (AA 500-900) (FITC)

N° du produit ABIN5564263

Détail du produit anti-TLR7 anticorps (FITC)

Antigène: TLR7 (Toll-Like Receptor 7 (TLR7))

Épitope: AA 500-900

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TLR7 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Specificité: Recognizes human TLR7.

Réactivité croisée: Humain

Purification: Protein G purified.

Immunogène: Recombinant human TLR7 protein (aa 500-900).

Clone: ABM2C27

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In 10 mM TRIS containing 150 mM NaCl and 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: +4°C
Stable for at least 6 months after receipt when stored at +4°C.

Date de péremption: 6 months

Détails sur TLR7

Antigène: TLR7 (Toll-Like Receptor 7 (TLR7))

Autre désignation: TLR7 (TLR7 Produits)

Synonymes: anticorps TLR7-like, anticorps RGD1563357, anticorps toll like receptor 7, anticorps toll-like receptor 7, anticorps TLR7, anticorps Tlr7

Sujet: TLR7 (Toll-like Receptor 7) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is a nucleotide-sensing TLR. TLR7 and TLR8 recognize single-stranded RNA (ssRNA) sequences containing GU-rich or poly-U sequences as their natural ligands, and they are also activated by synthetic small-molecular-weight compounds of the imidazoquinoline family. Both TLR7 and TLR8 signal via MYD88 and TRAF6, leading to NF-kappaB and antiviral factor, such as IRF family activation, cytokine secretion and the inflammatory response. They are localized intracellularly to endosomal membranes and act as potent activators of innate immune responses upon viral infection. The TLR7 gene is predominantly expressed in lung, placenta and spleen, and lies in close proximity to TLR8 on chromosome X. TLR7 has been shown to play a significant role in the pathogenesis of autoimmune disorders such as Systemic Lupus Erythematosus (SLE) as well as in the regulation of antiviral immunity. Recently, small molecule TLR7/8 agonists have demonstrated potential as vaccine adjuvants, since they directly activate APCs and can enhance both humoral and cellular immune responses, especially Th1 responses. This makes the TLR7/8 signaling pathways interesting therapeutic targets.

Pathways: Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades