IFT57 anticorps (AA 159-193)

N° du produit ABIN5647795

Détail du produit anti-IFT57 anticorps

Antigène: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Épitope: AA 159-193

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFT57 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée (Details): Expected species reactivity: Bovine

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 159-193 from the human protein was used as the immunogen for the HIPPI antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the HIPPI antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western Blot: 1:2000

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the HIPPI antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur IFT57

Antigène: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Autre désignation: HIPPI (IFT57 Produits)

Synonymes: anticorps Esrrbl1, anticorps 4833420A15Rik, anticorps Hippi, anticorps MHS4R2, anticorps ESRRBL1, anticorps HIPPI, anticorps intraflagellar transport 57, anticorps intraflagellar transport 57 S homeolog, anticorps Ift57, anticorps IFT57, anticorps ift57.S

Sujet: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator, however the relevance of such function remains unclear.

UniProt: Q9NWB7

Pathways: Signalisation Hedgehog, Positive Regulation of Endopeptidase Activity