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AIMP2 anticorps (AA 150-200)
AIMP2
Reactivité: Humain
WB, ELISA, IHC (p), IF
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN5688957
Détail du produit anti-AIMP2 anticorps
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Antigène
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AIMP2
(Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))
Épitope
Tous les épitopes à travers AIMP2 Anticorps.
AA 150-200
Reactivité
Toutes les réactivités sur AIMP2 Anticorps
Humain
Hôte
Toutes les hôtes sur AIMP2 Anticorps
Lapin
Clonalité
Toutes les clonalités sur AIMP2 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers AIMP2 Anticorps
Cet anticorp AIMP2 est non-conjugé
Application
Tous les applications à travers AIMP2 Anticorps.
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
Specificité
AIMP2 antibody is human specific. AIMP2 antibody is predicted to not cross-react with AIMP1.
Purification
AIMP2 antibody is affinity chromatography purified via peptide column.
Immunogène
AIMP2 antibody was raised against a 16 amino acid peptide near the center of human AIMP2. The immunogen is located within amino acids 150 - 200 of AIMP2.
Isotype
IgG
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Information d'application
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Indications d'application
AIMP2 antibody can be used for detection of AIMP2 by Western blot at 1 - 2 μ,g/mL.
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
1 mg/mL
Buffer
AIMP2 antibody is supplied in PBS containing 0.02 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
AIMP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Détails sur AIMP2
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Antigène
AIMP2
(Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))
Autre désignation
AIMP2 (AIMP2 Produits )
Synonymes
anticorps jtv1, anticorps MGC53242, anticorps pro0992, anticorps JTV1, anticorps JTV-1, anticorps P38, anticorps AA407136, anticorps AA407225, anticorps Aimp2(p38), anticorps Jtv1, anticorps aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 L homeolog, anticorps aminoacyl tRNA synthetase complex-interacting multifunctional protein 2, anticorps aminoacyl tRNA synthetase complex interacting multifunctional protein 2, anticorps aimp2.L, anticorps aimp2, anticorps AIMP2, anticorps Aimp2
Sujet
AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1). It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson's disease, accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2). AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3). Finally, AIMP2 has been suggested to function as a tumor suppressor (4).
Poids moléculaire
Predicted: 35 kDa Observed: 36 kDa
ID gène
7965
NCBI Accession
NP_006294
UniProt
Q13155
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