ATM anticorps (AA 1979-1983)

N° du produit ABIN5689237

L’anticorps Lapin Polyclonal anti-ATM a été validé pour WB et IF. Il convient pour détecter ATM dans des échantillons de Humain et Souris.

Aperçu rapide pour ATM anticorps (AA 1979-1983) (ABIN5689237)

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATM est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-ATM anticorps

Épitope: AA 1979-1983

Specificité: This antibody detects endogenous level of total ATM protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: ATM (Ab-1981) antibody was raised against a peptide sequence around aa.1979~1983 (E-G-S-Q-S) derived from Human ATM.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur ATM

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Autre désignation: ATM

Sujet: ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 350 kDa

ID gène: 472

NCBI Accession: NP_000042

UniProt: Q13315

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus