PTPN5 anticorps (AA 180-230)

N° du produit ABIN5690111

Détail du produit anti-PTPN5 anticorps

Antigène: PTPN5 (Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5))

Épitope: AA 180-230

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTPN5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificité: PTPN5 antibody is human and mouse reactive.

Purification: PTPN5 antibody is affinity chromatography purified via peptide column.

Immunogène: PTPN5 antibody was raised against an 18 amino acid peptide near the amino terminus of human PTPN5.

The immunogen is located within amino acids 180 - 230 of PTPN5.

Isotype: IgG

Information d'application

Indications d'application: PTPN5 antibody can be used for detection of PTPN5 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PTPN5 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: PTPN5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur PTPN5

Antigène: PTPN5 (Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5))

Autre désignation: PTPN5 (PTPN5 Produits)

Synonymes: anticorps STEP, anticorps Step, anticorps PTPSTEP, anticorps protein tyrosine phosphatase, non-receptor type 5, anticorps ptpn5, anticorps PTPN5, anticorps Ptpn5

Sujet: The protein tyrosine phosphatase PTPN5, also known as Striatal enriched phosphatase (STEP), is involved in the regulation of synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (1). It is expressed in dopaminoceptive neurons of the central nervous system and multiple forms of PTPN5 show differential enrichment in adult brain regions (2). NMDA-mediated activation of PTPN5 is an important mechanism for regulation of Erk activity in neurons (3). Furthermore, PTPN5 is involved in the regulation of both NMDAR and AMPAR trafficking (4,5). PTPN5 may play a role in Alzheimer's disease (1).

Poids moléculaire: Predicted: 62 kDa

Observed: 60 kDa

ID gène: 84867

NCBI Accession: NP_008837

UniProt: Q86TL6