Neuroserpin anticorps

N° du produit ABIN5690556

Détail du produit anti-Neuroserpin anticorps

Antigène: Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neuroserpin est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hNeuroserpin (human Neuroserpin). Human Neuroserpin specific antibody was purified by affinity chromatography employing immobilized hNeuroserpin matrix.

Information d'application

Indications d'application: ELISA:
Indirect:
To detect hNeuroserpin by indirect ELISA (using 100 μ,L/well antibody solution) a concentration of 0.5 - 2.0 μ,g/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hNeuroserpin.

Sandwich
To detect hNeuroserpin by sandwich ELISA (using 100 μ,L/well antibody solution) a concentration of 0.5 - 2.0 μ,g/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with our biotinylated Anti-Human Neuroserpin as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hNeuroserpin.

Western Blot:
To detect hNeuroserpin by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 μ,g/mL. Used in conjunction with compatible secondary reagents the detection limit for recombinant hNeuroserpin is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Stock: -20 °C

Stockage commentaire: Neuroserpin antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. Avoid repeated freeze-thaw cycles.

Détails sur Neuroserpin

Antigène: Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))

Autre désignation: Neuroserpin (SERPINI1 Produits)

Synonymes: anticorps PI12, anticorps neuroserpin, anticorps AI837402, anticorps Ns, anticorps PI-12, anticorps Spi17, anticorps CG9453, anticorps Dmel\\CG9453, anticorps Serp2, anticorps Sp4, anticorps Spn4, anticorps Spn4A, anticorps dSerp2, anticorps sp4, anticorps spn4, anticorps raPIT5a, anticorps SERPINI1, anticorps pi12, anticorps serpini1l, anticorps si:ch211-167c22.4, anticorps serpin family I member 1, anticorps serine (or cysteine) peptidase inhibitor, clade I, member 1, anticorps Serpin 42Da, anticorps serpin peptidase inhibitor, clade I (neuroserpin), member 1, anticorps serpin family I member 1 L homeolog, anticorps SERPINI1, anticorps Serpini1, anticorps Spn42Da, anticorps serpini1, anticorps serpini1.L

Sujet: Neuroserpin is a member of the serpin superfamily and is predominantly expressed by neurons of the developing and adult brain. This serpin is secreted from axonal growth cones of the CNS and PNS where it inhibits the enzyme tissue plasminogen activator. The expression pattern of neuroserpin and its in vivo inhibitory activity implicate this serpin in regulating axonal growth, reducing seizure activity, controlling damage in cerebral infarction and regulating emotional behaviour and memory. Four different mutations have been described in the human neuroserpin gene that promote neuroserpin abnormal polymerization, giving rise to intraneuronal inclusion bodies and a new form of dementia called Familial Encephalopathy with Neuroserpin Inclusion Bodies.

ID gène: 5274

UniProt: Q99574

Pathways: Regulation of Hormone Metabolic Process