Caspase 2 anticorps

N° du produit ABIN5690633

Détail du produit anti-Caspase 2 anticorps

Antigène: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Reactivité: Humain, Souris, Rat, Chien, Singe

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Specificité: Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2. Detects bands of ~51  kDa (procaspase-2), ~32  kDa and ~18  kDa (cleavage products) by Western blot.

Pureté: > 95% (SDS-PAGE)

Immunogène: Recombinant human caspase-2 (p19 subunit).

Clone: 11B4

Isotype: IgG2a kappa

Information d'application

Indications d'application: Immunoprecipitation: (1-5 μg/mL) . Western Blot: (1-2 μg/mL) . Optimal conditions must be determined individually for each application.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for at least 1 year after receipt when stored at -20°C.

Détails sur Caspase 2

Antigène: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Autre désignation: Caspase-2 (CASP2 Produits)

Synonymes: anticorps xCaspase-2, anticorps Caspase-2, anticorps ICH-1, anticorps Nedd2, anticorps CASP-2, anticorps ICH1, anticorps NEDD-2, anticorps NEDD2, anticorps PPP1R57, anticorps ICH-1L/1S, anticorps ICH1L1S, anticorps caspase 2, anticorps caspase 2 L homeolog, anticorps caspase-2, anticorps CASP2, anticorps casp2.L, anticorps CpipJ_CPIJ008254, anticorps Casp2

Sujet: Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation cascade of caspases responsible for apoptosis execution. Activation occurs upon recruitment to a complex containing a p53-induced death domain protein, PIDD. This suggests caspase-2 can be a nuclear initiator caspase with a requirement for caspase-9 and caspase-3 activation in downstream apoptotic events. In apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of mitochondrial dysfunction and of caspase-9 and caspase-3 activation, extending a possible role for caspase-2 as a parallel effector caspase.

ID gène: 835

UniProt: P42575

Pathways: Apoptose, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway