CNOT1 anticorps

N° du produit ABIN5697246

Détail du produit anti-CNOT1 anticorps

Antigène: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CNOT1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Immunogène: CCR4-NOT transcription complex, subunit 1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

human brain tissue were subjected to SDS PAGE followed by western blot with FNab01805(CNOT1 antibody) at dilution of 1:800

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur CNOT1

Antigène: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Autre désignation: CNOT1 (CNOT1 Produits)

Synonymes: anticorps CDC39, anticorps NOT1, anticorps NOT1H, anticorps 6030411K04Rik, anticorps AA815922, anticorps D830048B13, anticorps RGD1308009, anticorps GB18988, anticorps cdc39-like, anticorps im:7141761, anticorps kiaa1007l, anticorps wu:fc58h04, anticorps zgc:152902, anticorps CNOT1, anticorps not1, anticorps cdc39, anticorps not1h, anticorps ad-005, anticorps NV18106, anticorps CCR4-NOT transcription complex subunit 1, anticorps CCR4-NOT transcription complex, subunit 1, anticorps CNOT1, anticorps Cnot1, anticorps LOC412371, anticorps cnot1, anticorps LOC100114396

Sujet: Synonyms:CDC39, KIAA1007, NOT1 Background:Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element(ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem(ES) cell identity.

Poids moléculaire: 240-250 kDa,174 kDa

ID gène: 23019

UniProt: A5YKK6

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance