VRK2 anticorps

N° du produit ABIN5698696

Détail du produit anti-VRK2 anticorps

Antigène: VRK2 (Vaccinia Related Kinase 2 (VRK2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VRK2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Immunogène: vaccinia related kinase 2

Isotype: IgG

Information d'application

Indications d'application: WB :1:500-1:5000,IP:1:200-1:2000

Commentaires:

K-562 cells were subjected to SDS PAGE followed by western blot with FNab09452(VRK2 antibody) at dilution of 1:500

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur VRK2

Antigène: VRK2 (Vaccinia Related Kinase 2 (VRK2))

Autre désignation: VRK2 (VRK2 Produits)

Synonymes: anticorps 2810003O05Rik, anticorps AI447698, anticorps vaccinia related kinase 2, anticorps VRK2, anticorps Vrk2

Sujet: Synonyms:Vaccinia related kinase 2, VRK2 Background:Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta(IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase(MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant. Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.

Poids moléculaire: 151kDa

ID gène: 7444

UniProt: Q86Y07