DTX3L anticorps

N° du produit ABIN5698856

Détail du produit anti-DTX3L anticorps

Antigène: DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DTX3L est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: deltex 3-like (Drosophila)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur DTX3L

Antigène: DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))

Autre désignation: DTX3L (DTX3L Produits)

Synonymes: anticorps BBAP, anticorps RGD1565144, anticorps AU042200, anticorps BC023741, anticorps DTX3L, anticorps deltex E3 ubiquitin ligase 3L, anticorps deltex 3-like, E3 ubiquitin ligase, anticorps probable E3 ubiquitin-protein ligase DTX3, anticorps DTX3L, anticorps Dtx3l, anticorps LOC100521724

Sujet: Synonyms:BBAP Background:Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4(H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation(H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

Poids moléculaire: 84 kDa

ID gène: 151636

UniProt: Q8TDB6

Pathways: Signalisation Notch