SREBF chaperone anticorps
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- Antigène Voir toutes SREBF chaperone (SCAP) Anticorps
- SREBF chaperone (SCAP)
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SREBF chaperone est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Immunogène
- SREBF chaperone
- Isotype
- IgG
- Top Product
- Discover our top product SCAP Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab07622(SCAP antibody) at dilution of 1:300
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- SREBF chaperone (SCAP)
- Autre désignation
- SCAP (SCAP Produits)
- Synonymes
- anticorps 9530044G19, anticorps mKIAA0199, anticorps SREBF chaperone, anticorps SREBF chaperone S homeolog, anticorps SCAP, anticorps Scap, anticorps scap.S
- Sujet
- Synonyms:KIAA0199 Background:Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway(By similarity).SCAP has 4 isoforms with MW 140, 98, 96 and 85 kDa (refer to UniProt: Q12770).
- ID gène
- 22937
- UniProt
- Q12770
- Pathways
- SARS-CoV-2 Protein Interactome
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