NEIL1 anticorps

N° du produit ABIN5701138

Détail du produit anti-NEIL1 anticorps

Antigène: NEIL1 (Endonuclease VIII-Like 1 (NEIL1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEIL1 est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: nei endonuclease VIII-like 1 (E. coli)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur NEIL1

Antigène: NEIL1 (Endonuclease VIII-Like 1 (NEIL1))

Autre désignation: NEIL1 (NEIL1 Produits)

Synonymes: anticorps FPG1, anticorps NEI1, anticorps hFPG1, anticorps 2810450N13Rik, anticorps Nei1, anticorps nei-like DNA glycosylase 1, anticorps nei like DNA glycosylase 1, anticorps nei endonuclease VIII-like 1 (E. coli), anticorps Neil1, anticorps NEIL1

Sujet: Synonyms:DNA glycosylase/AP lyase Neil1, Endonuclease 8 like 1, Endonuclease VIII like 1, FPG1, hFPG1, NEH1, Nei homolog 1, Nei like protein 1, NEI1, NEIL1 Background:Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine(Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP(apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'-and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine(5hmC), suggesting that it acts as a specific reader of 5hmC.

Poids moléculaire: 44 kDa

ID gène: 79661

UniProt: Q96FI4

Pathways: Réparation de l'ADN