TPX2 anticorps

N° du produit ABIN5701596

Détail du produit anti-TPX2 anticorps

Antigène: TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TPX2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Immunogène: TPX2, microtubule-associated, homolog (Xenopus laevis)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur TPX2

Antigène: TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))

Autre désignation: TPX2 (TPX2 Produits)

Synonymes: anticorps C20orf1, anticorps C20orf2, anticorps DIL-2, anticorps DIL2, anticorps FLS353, anticorps GD:C20orf1, anticorps HCA519, anticorps HCTP4, anticorps REPP86, anticorps p100, anticorps 2610005B21Rik, anticorps TPX2, anticorps dil-2, anticorps dil2, anticorps hctp4, anticorps repp86, anticorps tpx2, anticorps TPX2, microtubule nucleation factor, anticorps TPX2, microtubule-associated, anticorps TPX2, microtubule-associated, homolog (Xenopus laevis), anticorps TPX2, microtubule-associated S homeolog, anticorps TPX2, microtubule-associated L homeolog, anticorps TPX2, anticorps Tpx2, anticorps tpx2.S, anticorps tpx2.L

Sujet: Synonyms:C20orf1, C20orf2, DIL2, HCA519 Background:Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules(PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation(PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha(PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation(PubMed:26165940).

ID gène: 22974

UniProt: Q9ULW0