AP2A2 anticorps

N° du produit ABIN5701668

Détail du produit anti-AP2A2 anticorps

Antigène: AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AP2A2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Immunogène: adaptor-related protein complex 2, alpha 2 subunit

Isotype: IgG

Information d'application

Indications d'application: WB : 1:200-1:1000 IHC : 1:20-1:200

Commentaires:

mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab00461( AP2A2 Antibody) at dilution of 1:500

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur AP2A2

Antigène: AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))

Autre désignation: AP2A2 (AP2A2 Produits)

Synonymes: anticorps MGC99219, anticorps ADTAB, anticorps CLAPA2, anticorps HIP-9, anticorps HIP9, anticorps HYPJ, anticorps 2410074K14Rik, anticorps AF006990, anticorps AW146353, anticorps Adtab, anticorps C78001, anticorps L25, anticorps adaptor related protein complex 2 alpha 2 subunit, anticorps adaptor related protein complex 2 alpha 2 subunit L homeolog, anticorps adaptor-related protein complex 2, alpha 2 subunit, anticorps AP2A2, anticorps ap2a2.L, anticorps Ap2a2

Sujet: Synonyms:ADTAB, CLAPA2, HIP9, HYPJ, KIAA0899 Background:Component of the adaptor protein complex 2(AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin(clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein(AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV](Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif(By similarity).

Poids moléculaire: 104 kDa

ID gène: 161

UniProt: O94973

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation, SARS-CoV-2 Protein Interactome