ATG7 anticorps

N° du produit ABIN5702085

Détail du produit anti-ATG7 anticorps

Antigène: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG7 est non-conjugé

Application: ELISA

Immunogène: ATG7 autophagy related 7 homolog (S. cerevisiae)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur ATG7

Antigène: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Autre désignation: ATG7 (ATG7 Produits)

Synonymes: anticorps APG7-LIKE, anticorps APG7L, anticorps GSA7, anticorps D8, anticorps UBA1B, anticorps UBE1L, anticorps UBE2, anticorps Ube1l, anticorps 1300004C08Rik, anticorps AO090001000744, anticorps atg7, anticorps 1810013K23Rik, anticorps Agp7, anticorps Apg7l, anticorps Atg7l, anticorps ATAPG7, anticorps ATATG7, anticorps ATG7, anticorps AUTOPHAGY 7, anticorps AUTOPHAGY-RELATED 7, anticorps K15I22.10, anticorps K15I22_10, anticorps autophagy related 7, anticorps ubiquitin like modifier activating enzyme 7, anticorps ubiquitin-like modifier activating enzyme 7, anticorps autophagy-related protein 7, anticorps Autophagy-related protein 7, anticorps Apg7p, anticorps ThiF family protein, anticorps ubiquitin-like conjugating enzyme Atg7, anticorps ATG7, anticorps UBA7, anticorps Uba7, anticorps ANI_1_3368024, anticorps AOR_1_1338164, anticorps PTRG_02236, anticorps PAAG_00287, anticorps PITG_12537, anticorps atg7, anticorps Atg7, anticorps APG7

Sujet: Synonyms:APG7L Background:E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport(Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.

ID gène: 10533

UniProt: O95352

Pathways: Response to Water Deprivation, Autophagy