TSEN2 anticorps

N° du produit ABIN5702355

Détail du produit anti-TSEN2 anticorps

Antigène: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSEN2 est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: tRNA splicing endonuclease 2 homolog (S. cerevisiae)

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:5000

Commentaires:

human brain tissue were subjected to SDS PAGE followed by western blot with FNab09038(TSEN2 antibody) at dilution of 1:400

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur TSEN2

Antigène: TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))

Autre désignation: TSEN2 (TSEN2 Produits)

Synonymes: anticorps AU067695, anticorps RGD1309946, anticorps PCH2B, anticorps SEN2, anticorps SEN2L, anticorps tRNA splicing endonuclease subunit 2, anticorps TSEN2, anticorps Tsen2

Sujet: Synonyms:HsSen2, PCH2B, SEN2, SEN2L, tRNA intron endonuclease Sen2, TSEN2 Background:Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'-and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.

Poids moléculaire: 45kDa

ID gène: 80746

UniProt: Q8NCE0

Pathways: Nuclear Receptor Transcription Pathway, Regulation of Lipid Metabolism by PPARalpha