KIDINS220 anticorps

N° du produit ABIN5702622

Détail du produit anti-KIDINS220 anticorps

Antigène: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIDINS220 est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: kinase D-interacting substrate, 220kDa

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur KIDINS220

Antigène: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Autre désignation: KIDINS220 (KIDINS220 Produits)

Synonymes: anticorps ARMS, anticorps fj35h03, anticorps kidins220, anticorps zgc:63531, anticorps dZ119J18.2, anticorps wu:fj35h03, anticorps 3110039L19Rik, anticorps AI194387, anticorps AI316525, anticorps C330002I19Rik, anticorps mKIAA1250, anticorps kinase D interacting substrate 220, anticorps kinase D-interacting substrate 220, anticorps kinase D-interacting substrate 220b, anticorps kinase D-interacting substrate 220kDa, anticorps KIDINS220, anticorps Kidins220, anticorps kidins220b

Sujet: Synonyms:ARMS, KIAA1250 Background:Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor(NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration(By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Poids moléculaire: 186-197 kDa

ID gène: 57498

UniProt: Q9ULH0