KHDRBS3 anticorps

N° du produit ABIN5703054

Détail du produit anti-KHDRBS3 anticorps

Antigène: KHDRBS3 (KH Domain Containing, RNA Binding, Signal Transduction Associated 3 (KHDRBS3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KHDRBS3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogène: KH domain containing, RNA binding, signal transduction associated 3

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04523(KHDRBS3 antibody) at dilution of 1:300

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur KHDRBS3

Antigène: KHDRBS3 (KH Domain Containing, RNA Binding, Signal Transduction Associated 3 (KHDRBS3))

Autre désignation: KHDRBS3 (KHDRBS3 Produits)

Synonymes: anticorps KHDRBS3, anticorps T-STAR, anticorps Etle, anticorps SALP, anticorps SLM-2, anticorps SLM2, anticorps TSTAR, anticorps etoile, anticorps Slm2, anticorps KH domain containing, RNA binding, signal transduction associated 3, anticorps KH RNA binding domain containing, signal transduction associated 3, anticorps KHDRBS3, anticorps Khdrbs3

Sujet: Synonyms:SALP, SLM2 Background:RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6(PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor(PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer(By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4(AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members(PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity(By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing(By similarity). Can bind FABP9 mRNA(By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression.

Poids moléculaire: 55 kDa

ID gène: 10656

UniProt: O75525