FBXW5 anticorps
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- Antigène Voir toutes FBXW5 Anticorps
- FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FBXW5 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogène
- F-box and WD repeat domain containing 5
- Isotype
- IgG
- Top Product
- Discover our top product FBXW5 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab03056( FBXW5 Antibody) at dilution of 1:600
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))
- Autre désignation
- FBXW5 (FBXW5 Produits)
- Synonymes
- anticorps Fbw5, anticorps AI159739, anticorps F-box and WD repeat domain containing 5, anticorps F-box and WD-40 domain protein 5, anticorps FBXW5, anticorps Fbxw5
- Sujet
- Synonyms:FBW5 Background:Substrate recognition component of both SCF(SKP1-CUL1-F-box protein) and DCX(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B(IL1B) signaling pathway.
- Poids moléculaire
- 65 kDa
- ID gène
- 54461
- UniProt
- Q969U6
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