PMEPA1 anticorps

N° du produit ABIN5704584

Détail du produit anti-PMEPA1 anticorps

Antigène: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PMEPA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Immunogène: prostate transmembrane protein, androgen induced 1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

L02 cells were subjected to SDS PAGE followed by western blot with FNab06569( PMEPA1 Antibody) at dilution of 1:600

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur PMEPA1

Antigène: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Autre désignation: PMEPA1 (PMEPA1 Produits)

Synonymes: anticorps Tmepai, anticorps PMEPA1, anticorps TMEPAI, anticorps zgc:92731, anticorps tmepai, anticorps STAG1, anticorps 2210418I02Rik, anticorps AW455466, anticorps Erg1.2, anticorps N4wbp4, anticorps Stag1, anticorps prostate transmembrane protein, androgen induced 1, anticorps prostate transmembrane protein, androgen induced 1 L homeolog, anticorps Pmepa1, anticorps PMEPA1, anticorps pmepa1, anticorps pmepa1.L

Sujet: Synonyms:STAG1, TMEPAI Background:Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal(PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor(AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4(PubMed:18703514).

ID gène: 56937

UniProt: Q969W9

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway