JMY anticorps
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- Antigène Voir toutes JMY Anticorps
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp JMY est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Immunogène
- junction mediating and regulatory protein, p53 cofactor
- Isotype
- IgG
- Top Product
- Discover our top product JMY Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Jurkat cells were subjected to SDS PAGE followed by western blot with FNab04443( JMY Antibody) at dilution of 1:1000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
- Autre désignation
- JMY (JMY Produits)
- Synonymes
- anticorps WHDC1L3, anticorps junction mediating and regulatory protein, p53 cofactor, anticorps junction-mediating and regulatory protein, anticorps JMY, anticorps jmy, anticorps Jmy
- Sujet
- Synonyms:JMY, WHDC1L3 Background:Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location(By similarity).
- Poids moléculaire
- 111 kDa
- ID gène
- 133746
- UniProt
- Q8N9B5
- Pathways
- Regulation of Actin Filament Polymerization
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