YTHDC1 anticorps
-
- Antigène Voir toutes YTHDC1 Anticorps
- YTHDC1 (YTH Domain Containing 1 (YTHDC1))
-
Reactivité
- Humain, Souris, Rat
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp YTHDC1 est non-conjugé
-
Application
- Western Blotting (WB), ELISA
- Immunogène
- YTH domain containing 1
- Isotype
- IgG
- Top Product
- Discover our top product YTHDC1 Anticorps primaire
-
-
- Indications d'application
- WB : 1:200-1:1000
- Commentaires
-
MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab09571( YTHDC1 Antibody) at dilution of 1:300
- Restrictions
- For Research Use only
-
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
-
- Antigène
- YTHDC1 (YTH Domain Containing 1 (YTHDC1))
- Autre désignation
- YTHDC1 (YTHDC1 Produits)
- Synonymes
- anticorps C80342, anticorps mKIAA1966, anticorps A730098D12Rik, anticorps zgc:101592, anticorps MGC89461, anticorps MGC137509, anticorps DKFZp459L1228, anticorps YT521, anticorps YT521-B, anticorps Yt521, anticorps YTH domain containing 1, anticorps YTH domain containing 1 L homeolog, anticorps Ythdc1, anticorps YTHDC1, anticorps ythdc1, anticorps ythdc1.L
- Sujet
- Synonyms:KIAA1966, Putative splicing factor YT521, YT521, YT521 B, YTH domain containing 1, YTHDC1 Background:Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs(PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10(PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing(PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing(PubMed:26876937). May also regulate alternative splice site selection(PubMed:20167602).
- Poids moléculaire
- 14kDa
- ID gène
- 91746
- UniProt
- Q96MU7
-