PARN anticorps

N° du produit ABIN5708342

Détail du produit anti-PARN anticorps

Antigène: PARN (Poly A Specific Ribonuclease (PARN))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARN est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogène: A recombinant human protein corresponding to amino acids M1-Y301 was used as the immunogen for the PARN antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PARN antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL, IHC (FFPE): 1-2 μg/mL, Direct ELISA: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the PARN antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur PARN

Antigène: PARN (Poly A Specific Ribonuclease (PARN))

Autre désignation: PARN (PARN Produits)

Synonymes: anticorps parn-A, anticorps xparn, anticorps DAN, anticorps RGD1565449, anticorps zgc:56067, anticorps 1200003I18Rik, anticorps poly(A)-specific ribonuclease L homeolog, anticorps poly(A)-specific ribonuclease, anticorps poly(A)-specific ribonuclease (deadenylation nuclease), anticorps parn.L, anticorps PARN, anticorps Parn, anticorps parn

Sujet: Poly(A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is encoded by the PARN gene. The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons.

UniProt: O95453