Src anticorps (Tyr419)

N° du produit ABIN5961533

Cet anticorps Lapin Polyclonal détecte spécifiquement Src dans WB, ELISA, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Src anticorps (Tyr419) (ABIN5961533)

Antigène: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Src est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Src anticorps

Épitope: Tyr419

Specificité: ASV,Avian sarcoma virus,c SRC,CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA,cSrc,EC 2.7.10.2,Neuronal CSRC tyrosine specific protein kinase,Neuronal SRC,Oncogene SRC,OTTHUMP00000174476,OTTHUMP00000174477,p60 Src,p60-Src,p60Src,pp60c src,pp60c-src,pp60csrc,Proto oncogene tyrosine protein kinase Src,Proto-oncogene c-Src,Proto-oncogene tyrosine-protein kinase Src,Protooncogene SRC,Protooncogene SRC Rous sarcoma,Src,SRC Oncogene,SRC proto oncogene non receptor tyrosine kinase,SRC,SRC1,Tyrosine kinase pp60c src,Tyrosine protein kinase SRC 1,Tyrosine protein kinase SRC1,v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog,V src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog (avian),v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian

Purification: Affinity purification

Immunogène: Synthesized peptide derived from human c-Src around the non-phosphorylation site of Tyr419.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Src

Antigène: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Autre désignation: c-Src

Sujet: Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling.

Poids moléculaire: 60kDa

ID gène: 6714

UniProt: P12931

Pathways: Signalistation JAK/STAT, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling