ABCC8 anticorps (AA 700-1000)

N° du produit ABIN6224521

Détail du produit anti-ABCC8 anticorps

Antigène: ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))

Épitope: AA 700-1000

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABCC8 est non-conjugé

Application: Western Blotting (WB)

Séquence: TIRIPRGQLT MIVGQVGCGK SSLLLAALGE MQKVSGAVFW SSLPDSEIGE DPSPERETAT DLDIRKRGPV AYASQKPWLL NATVEENIIF ESPFNKQRYK MVIEACSLQP DIDILPHGDQ TQIGERGINL SGGQRQRISV ARALYQHANV VFLDDPFSAL DIHLSDHLMQ AGILELLRDD KRTVVLVTHK LQYLPHADWI IAMKDGTIQR EGTLKDFQRS ECQLFEHWKT LMNRQDQELE KETVTERKAT EPPQGLSRAM SSRDGLLQDE EEEEEEAAES EEDDNLSSML HQRAEIPWRA C

Réactivité croisée: Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human ABCC8 (NP_000343.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ABCC8

Antigène: ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))

Autre désignation: ABCC8 (ABCC8 Produits)

Synonymes: anticorps ABC36, anticorps HHF1, anticorps HI, anticorps HRINS, anticorps MRP8, anticorps PHHI, anticorps SUR, anticorps SUR1, anticorps SUR1delta2, anticorps TNDM2, anticorps D930031B21Rik, anticorps Sur, anticorps Sur1, anticorps ATP binding cassette subfamily C member 8, anticorps ATP-binding cassette, sub-family C (CFTR/MRP), member 8, anticorps ABCC8, anticorps Abcc8

Sujet: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene.,ABCC8,ABC36,HHF1,HI,HRINS,MRP8,PHHI,SUR,SUR1,SUR1delta2,TNDM2,Cancer,Signal Transduction,Endocrine & Metabolism,Drug metabolism,Endocrine and metabolic diseases,Diabetes,Cardiovascular,Heart,Cardiac arrhythmias,Cardiovascular diseases,Heart disease,ABCC8

Poids moléculaire: 5 kDa/176 kDa/177 kDa

ID gène: 6833

UniProt: Q09428

Pathways: Negative Regulation of Hormone Secretion