AFT7 anticorps (AA 1-117)

N° du produit ABIN6223488

Détail du produit anti-AFT7 anticorps

Antigène: AFT7 (Activating Transcription Factor 7 (AFT7))

Épitope: AA 1-117

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AFT7 est non-conjugé

Application: Western Blotting (WB)

Séquence: MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ TPTPTRFLKN CEEVGLFNEL ASSFEHEFKK AADEDEKKAR SRTVAKKLVV FRPRLFLLCF GIIFLIG

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-117 of human ATF7 (NP_001193611.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur AFT7

Antigène: AFT7 (Activating Transcription Factor 7 (AFT7))

Autre désignation: ATF7 (AFT7 Produits)

Synonymes: anticorps ATFA, anticorps 1110012F10Rik, anticorps 9430065F09Rik, anticorps AI549878, anticorps C130020M04Rik, anticorps ATF7, anticorps fa97a09, anticorps fc25b12, anticorps wu:fa97a09, anticorps wu:fc25b12, anticorps atfa, anticorps activating transcription factor 7, anticorps activating transcription factor 7b, anticorps ATF7, anticorps Atf7, anticorps atf7b, anticorps atf7

Sujet: Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes (By similarity. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (By similarity. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening. Plays also a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (By similarity.,ATF7,ATFA,Epigenetics & Nuclear Signaling,Transcription Factors,ATF7

Poids moléculaire: 13 kDa/33 kDa/49 kDa/50 kDa/51 kDa/52 kDa

ID gène: 11016

UniProt: P17544