DFFB anticorps (AA 109-338)

N° du produit ABIN6139552

Détail du produit anti-DFFB anticorps

Antigène: DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))

Épitope: AA 109-338

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DFFB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: DEQAPQRQRL LADLLHNVSQ NIAAETRAED PPWFEGLESR FQSKSGYLRY SCESRIRSYL REVSSYPSTV GAEAQEEFLR VLGSMCQRLR SMQYNGSYFD RGAKGGSRLC TPEGWFSCQG PFDMDSCLSR HSINPYSNRE SRILFSTWNL DHIIEKKRTI IPTLVEAIKE QDGREVDWEY FYGLLFTSEN LKLVHIVCHK KTTHKLNCDP SRIYKPQTRL KRKQPVRKRQ

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 109-338 of human DFFB (NP_004393.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:200 - 1:1000,IHC,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur DFFB

Antigène: DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))

Autre désignation: DFFB (DFFB Produits)

Synonymes: anticorps CAD, anticorps CPAN, anticorps DFF-40, anticorps DFF2, anticorps DFF40, anticorps LOC100223514, anticorps 40kDa, anticorps 5730477D02Rik, anticorps Didff, anticorps Cad, anticorps carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, anticorps DNA fragmentation factor subunit beta, anticorps DNA fragmentation factor, beta polypeptide (caspase-activated DNase), anticorps DNA fragmentation factor, beta subunit, anticorps CAD, anticorps DFFB, anticorps dffb, anticorps LOC100223514, anticorps Dffb

Sujet: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined.,DFFB,CAD,CPAN,DFF-40,DFF2,DFF40,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Death Receptor Signaling Pathway,Endocrine & Metabolism,DFFB

Poids moléculaire: 11 kDa/12 kDa/30 kDa/39 kDa

ID gène: 1677

UniProt: O76075

Pathways: Apoptose, Caspase Cascade in Apoptosis